Copied!

Pathway Search



Naphthalene degradation

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
1,2,3,4-tetrahydronaphthalene <=> 5,6,7,8-Tetrahydro-2-naphthoic_acid not assigned

Naphthyl-2-hydroxymethyl-succinyl_CoA <=> Naphthyl-2-oxomethyl-succinyl-CoA + 2 H+ 1.1

4-Hydroxymethylsalicylate + O2 + NADH + H+ <=> 3,4-dihydroxybenzyl_alcohol + NAD+ + H2O + CO2 1.14.13.1 salicylate 1-monooxygenase

4-methylsalicylate + O2 + NADH + H+ <=> 4-methylcatechol + CO2 + H2O + NAD+ 1.14.13.1 salicylate 1-monooxygenase

2,6-Naphthalenedisulfonic_acid + O2 <=> 1,2-Dihydroxynaphthalene-6-sulfonate + sulfite 1.14.99

2-hydroxy-3-methylbenzaldehyde + NAD+ + H2O <=> 3-methylsalicylate + NADH + H+ 1.2.1

H+ + salicylate + O2 + NADH <=> catechol + CO2 + H2O + NAD+ 1.14.13.1 salicylate 1-monooxygenase

2-methylnaphthalene + O2 + NADH + H+ <=> cis-1,2-Dihydroxy-1,2-dihydro-7-methylnaphthalene + NAD+ 1.14.12.12 naphthalene 1,2-dioxygenase

1-Naphthalenesulfonic_acid + O2 <=> 1,2-dihydroxynaphthalene + sulfite 1.14.99

salicylate + NADPH + H+ + O2 <=> 2,5-Dihydroxybenzoate + NADP+ + H2O 1.14.13.172 salicylate 5-hydroxylase

2-methylnaphthalene + O2 + NADH + H+ <=> 2-naphthalenemethanol + NAD+ + H2O 1.14.13

cis-1,2-Dihydroxy-1,2-dihydro-8-carboxynaphthalene <=> 1,2-Dihydroxy-8-carboxynaphthalene 1.1

2-naphthoic_acid <=> 5,6,7,8-Tetrahydro-2-naphthoic_acid not assigned

1-naphthoic_acid + O2 + NADH + H+ <=> cis-1,2-Dihydroxy-1,2-dihydro-8-carboxynaphthalene + NAD+ 1.14.12

2-Hydroxy-7-hydroxymethylchromene-2-carboxylate <=> 2-Hydroxy-4-hydroxymethylbenzalpyruvate 5.3.99

(Z)-4-(2-Hydroxy-5-sulfonatophenyl)-2-oxo-3-butenoate + 2 H2O <=> 5-sulfosalicylic_acid + pyruvate not assigned

3-methylsalicylate + NADH + O2 <=> 3-methylcatechol + CO2 + NAD+ + H2O 1.14.13.1 salicylate 1-monooxygenase

1-methylnaphthalene + O2 + NADH + H+ <=> cis-1,2-Dihydroxy-1,2-dihydro-8-methylnaphthalene + NAD+ 1.14.12.12 naphthalene 1,2-dioxygenase

5,6,7,8-Tetrahydro-2-naphthoic_acid <=> Decahydro-2-naphthoic_acid not assigned

2-Hydroxy-8-methylchromene-2-carboxylate <=> 2-Hydroxy-3-methylbenzalpyruvate 5.3.99

(1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD+ <=> 1,2-dihydroxynaphthalene + NADH + H+ 1.3.1.29 cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase

cis-1,2-Dihydroxy-1,2-dihydro-7-hydroxymethylnaphthalene + NAD+ <=> 1,2-Dihydroxy-7-hydroxymethylnaphthalene + NADH + H+ 1.3.1.29 cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase

1,2-Dihydroxy-7-hydroxymethylnaphthalene + O2 <=> 2-Hydroxy-7-hydroxymethylchromene-2-carboxylate 1.13

salicylate + O2 + NADH + H+ <=> 2,5-Dihydroxybenzoate + NAD+ + H2O 1.14.13.172 salicylate 5-hydroxylase

Naphthyl-2-oxomethyl-succinyl-CoA + CoA <=> 2-Naphthoyl-CoA + succinyl-CoA 2.3.1

2-Hydroxy-3-methylbenzalpyruvate + H2O <=> 2-hydroxy-3-methylbenzaldehyde + pyruvate 4.2.1

2-Naphthalenesulfonic_acid + O2 <=> 1,2-dihydroxynaphthalene + sulfite 1.14.99

2-methylnaphthalene + fumarate <=> 2-Naphtylmethylsuccinic_acid 4.1.99

3-Formylsalicylic_acid + O2 + H2O <=> 2-Hydroxyisophthalic_acid + H2O2 1.2.3

2-naphthaldehyde <=> 4-Formylsalicylic_acid not assigned

1,6-Naphthalenedisulfonic_acid + O2 <=> 1,2-Dihydroxynaphthalene-6-sulfonate + sulfite 1.14.99

1,2-dihydroxynaphthalene + O2 <=> H+ + 2-hydroxy-2H-chromene-2-carboxylate 1.13.11.56 1,2-dihydroxynaphthalene dioxygenase

2-Carboxy-2-hydroxy-8-carboxychromene <=> 2-Hydroxy-3-carboxybenzalpyruvate 5.3.99

2-Hydroxyisophthalic_acid <=> salicylate + CO2 4.1.1

4-Hydroxymethylsalicylaldehyde + NAD+ + H2O <=> 4-Hydroxymethylsalicylate + NADH + H+ 1.2.1

1-methylnaphthalene + O2 + NADH + H+ <=> 1-naphthalene_methanol + NAD+ + H2O 1.14.13

2-Naphthoyl-CoA + H2O <=> 2-naphthoic_acid + CoA 2.8.3

2-hydroxy-2H-chromene-2-carboxylate <=> (3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate 2.5.1.18 glutathione transferase
5.99.1.4 2-hydroxychromene-2-carboxylate isomerase


5,6,7,8-Tetrahydro-2-naphthoic_acid <=> cis-2-Carboxycyclohexyl-acetic_acid not assigned

Naphthyl-2-methyl-succinyl-CoA <=> Naphthyl-2-methylene-succinyl-CoA + 2 H+ 1.3.99

1-naphthaldehyde + NAD+ + H2O <=> 1-naphthoic_acid + NADH 1.2.1
1.2.1.3 aldehyde dehydrogenase (NAD+)
1.2.1.39 phenylacetaldehyde dehydrogenase
1.2.1.65 salicylaldehyde dehydrogenase




2-Naphtylmethylsuccinic_acid + succinyl-CoA <=> Naphthyl-2-methyl-succinyl-CoA + succinate 2.8.3

1,2-Dihydroxy-8-methylnaphthalene + O2 <=> 2-Hydroxy-8-methylchromene-2-carboxylate 1.13

2-naphthaldehyde + NAD+ + H2O <=> 2-naphthoic_acid + NADH 1.2.1
1.2.1.16 succinate-semialdehyde dehydrogenase [NAD(P)+]
1.2.1.28 benzaldehyde dehydrogenase (NAD+)
1.2.1.3 aldehyde dehydrogenase (NAD+)
1.2.1.65 salicylaldehyde dehydrogenase





Salicylaldehyde + NAD+ + H2O <=> salicylate + NADH + H+ 1.2.1
1.2.1.24 succinate-semialdehyde dehydrogenase (NAD+)
1.2.1.28 benzaldehyde dehydrogenase (NAD+)
1.2.1.3 aldehyde dehydrogenase (NAD+)
1.2.1.64 4-hydroxybenzaldehyde dehydrogenase (NAD+)
1.2.1.65 salicylaldehyde dehydrogenase






2-naphthalenemethanol + O2 + NADH + H+ <=> cis-1,2-Dihydroxy-1,2-dihydro-7-hydroxymethylnaphthalene + NAD+ 1.14.12.12 naphthalene 1,2-dioxygenase

1,2-Dihydroxy-8-carboxynaphthalene + O2 <=> 2-Carboxy-2-hydroxy-8-carboxychromene 1.13

(3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate + H2O <=> Salicylaldehyde + pyruvate 4.1.2.45 trans-o-hydroxybenzylidenepyruvate hydratase-aldolase

1-naphthalene_methanol + NAD+ <=> 1-naphthaldehyde + NADH + H+ 1.1.1.1 alcohol dehydrogenase

2-Hydroxy-4-hydroxymethylbenzalpyruvate + H2O <=> 4-Hydroxymethylsalicylaldehyde + pyruvate 4.2.1

2-naphthoic_acid + FADH2 + O2 <=> 1-hydroxy-2-naphthoate + FAD + H2O not assigned

2-naphthalenemethanol + NAD+ <=> 2-naphthaldehyde + NADH 1.1.1.1 alcohol dehydrogenase
1.1.1.90 aryl-alcohol dehydrogenase


cis-1,2-Dihydroxy-1,2-dihydro-7-methylnaphthalene <=> 4-methylsalicylate not assigned

5-sulfosalicylic_acid + O2 <=> 2,5-Dihydroxybenzoate + sulfate not assigned

2-Hydroxy-3-carboxybenzalpyruvate + H2O <=> 3-Formylsalicylic_acid + pyruvate 4.2.1

cis-1,2-Dihydroxy-1,2-dihydro-8-methylnaphthalene + NAD+ <=> 1,2-Dihydroxy-8-methylnaphthalene + NADH + H+ 1.3.1.29 cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase

Naphthyl-2-methylene-succinyl-CoA + H2O <=> Naphthyl-2-hydroxymethyl-succinyl_CoA 4.2.1

H+ + Naphthalene + O2 + NADH <=> (1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD+ 1.14.12.12 naphthalene 1,2-dioxygenase
1.14.12.22 carbazole 1,9a-dioxygenase
1.14.12.23 nitroarene dioxygenase
1.14.12.24 2,4-dinitrotoluene dioxygenase




1,2-Dihydroxynaphthalene-6-sulfonate + O2 <=> (Z)-4-(2-Hydroxy-5-sulfonatophenyl)-2-oxo-3-butenoate 1.13.11

Visualization of the pathway